is Xeloda used for?
is used to treat:
- cancer of the colon or rectum that has spread to other parts of the
body (metastatic colorectal cancer) when fluoropyrimidine therapy
alone is preferred. Patients
and physicians should note that combination chemotherapy has shown a
survival benefit compared to 5-fluorouracil (5-FU)/oral leucovorin (
) alone. A
survival benefit over 5-FU/LV has not been demonstrated with Xeloda
- breast cancer that has spread to other parts of the body and has
not responded to treatment with certain other medicines. These
medicines include paclitaxel (TaxolŽ) and anthracycline-containing
therapy such as AdriamycinŽ and doxorubicin.
is changed in the body to the substance 5-fluorouracil. In
some patients with colon, rectum or breast cancer, this substance stops
cancer cells from growing and decreases the size of the tumor.
should not take Xeloda?
- You should not take Xeloda if you are allergic to 5-fluorouracil
(5-FU) because Xeloda is converted by the body to 5-FU.
- You should not
take Xeloda if you have severe renal impairment.
- You should not take Xeloda if you are nursing a baby.
Xeloda may pass into the milk and harm the baby.
Warnings Concerning Xeloda:
- Xeloda can cause diarrhea, which may be severe. If
you have more than 4 bowel movements a day, or diarrhea at night, stop
taking Xeloda and contact your doctor.
- Patients over 80 may have more gastrointestinal side effects such
as diarrhea, nausea, and vomiting.
- Xeloda may cause harm to your unborn child. Do not become
pregnant while taking Xeloda. Women
should use effective birth control. Men
should also practice birth control measures while taking Xeloda.
- Tell your doctor if you are taking a
drug that affects blood clotting such as CoumadinŽ or warfarin. After
Xeloda became available, there have been reports to the FDA of changes
in blood clotting and/or bleeding in people taking Xeloda together
with certain anticoagulants (blood thinners). See
your doctor regularly for monitoring.
Precautions with Xeloda:
can cause tingling, numbness, pain, swelling, or redness in the palms of
your hands or soles of your feet (hand and foot syndrome). Stop
taking Xeloda and contact your doctor if you have signs of this syndrome. Your
doctor may want to decrease your dose or stop your treatment with Xeloda.
should I tell my doctor or health care provider?
your doctor if you:
take a blood thinner such as warfarin (CoumadinŽ).
Xeloda may increase the effect of the blood thinner.
Your doctor will need to test your blood more often and adjust the
dose of your blood thinner if needed.
take phenytoin (DilantinŽ). Your
doctor will need to test your blood more often and adjust the dose if
have kidney problems.
have liver problems.
take the vitamin, folic acid.
are some possible side effects of Xeloda? (This is not a complete list of side effects reported with
Xeloda. Your health care provider can discuss with you a more complete
list of side effects.)
- diarrhea (see warnings)
- nausea - stop taking Xeloda and contact your doctor if you are not
able to eat or are only able to eat at certain times.
- vomiting - stop taking Xeloda and contact your doctor if you vomit
2-5 times or more in a 24-hour period.
- sores in mouth and throat - stop taking Xeloda and contact your
doctor if you have painful swelling and ulcers in your mouth or
- stomach pain
- decreased appetite
- hand-and-foot syndrome (see general precautions)
- dry or itchy skin
- fever - contact your doctor if you have a fever of 100.5°F
side effects may differ when taking Xeloda in combination with TaxotereŽ or
in combination with other chemotherapy. Please
consult your doctor for possible side effects that may be caused by taking
Xeloda with Taxotere or other chemotherapies.
more detailed information about Xeloda, ask your health care provider.