|What is Agenerase used for?
Agenerase is used to treat HIV-1
infection in combination with other anti-HIV medications. Agenerase belongs to the class
of anti-HIV medications called protease inhibitors and should only be taken in combination
with other anti-HIV medications.
Agenerase is not a cure for HIV infection. You may continue to develop
infections and other complications associated with HIV disease. Agenerase has not been
shown to reduce the risk of transmitting HIV to others through sexual contact or blood
contamination. The long-term effects of Agenerase are not known at this time.
Who should not take Agenerase?
There are potential drug interactions that can cause serious side effects. You
must not take Agenerase with:
- astemizole (Hismanal)
- bepridil (Vascor)
- cisapride (Propulsid)
- ergot derivatives (Cafergot and others)
- midazolam (Versed)
- triazolam (Halcion)
In addition, if you take certain other medications with Agenerase, serious or
life-threateningside effects can also occur. Because of this, it is very important that
you tell your doctor about all the medications you are taking, including those you take
without a prescription.
Special Warnings with Agenerase:
- Agenerase should not be taken alone to treat HIV. Because resistance to the HIV
virus can occur quickly with single drug treatment, Agenerase should always be taken in
combination with other anti-HIV medications. If your current treatment is
not working, contact your doctor; Agenerase should not be taken by itself.
- Talk to your doctor if you are taking Viagra (sildenafil) with Agenerase.
You may be at risk for an increase in Viagra-related side effects such as low blood
pressure, changes in vision, or penile erection lasting more than 4 hours.
- Increased blood sugar (hyperglycemia) or diabetes may develop while taking
Agenerase. If you take diabetes medication, your dose may need to be adjusted.
- Agenerase can cause a skin rash that is sometimes potentially severe and
life-threatening. If you develop a skin rash, tell your health care provider immediately.
- Agenerase may cause hemolytic anemia (a decrease in the number of red blood cells
in your body).
- Tell your health care provider if you are trying to become pregnant, are already
pregnant, or are breast-feeding. You should not become pregnant or breast-feed while
taking Agenerase. If you are using hormonal contraceptives (e.g., birth control pills),
you should use another form of birth control (e.g., condom, diaphragm) while taking
General Precautions with Agenerase:
If you are taking a blood-thinning medication or you have low vitamin K, your
doctor will decide if the amount of vitamin E in Agenerase interferes with your treatment.
Do not take vitamin E supplements while being treated with Agenerase, because Agenerase
contains vitamin E.
Agenerase may increase the amount of fat in your body or you may notice changes
in the location of your body fat. Tell your doctor if you experience any changes like
Do not switch from the capsule to the solution without advice from your doctor.
Agenerase capsules and Agenerase oral solution are not the same on a milligram per
Do not take additional vitamin E because the amount of vitamin E contained in
Agenerase is more than the Reference Daily Intake of vitamin E.
Do not refrigerate Agenerase capsules or oral solution. Store Agenerase at room
What should I tell my doctor or health care provider?
Tell your doctor or health care provider if you have:
- had an allergic reaction to sulfa drugs
- hemophilia, as hemophiliac patients have sometimes experienced spontaneous
bleeding while taking Agenerase
- a history of liver problems. Your health care provider will decide if Agenerase
is right for you.
What are some possible side effects of Agenerase? (This is NOT
a complete list of side effects reported with Agenerase. Your health care provider can
discuss with you a more complete list of side effects.)
Side effects may include:
- Skin rash (see Special Warnings)
- Tingling sensation around the mouth
Contact your doctor if you have nausea, vomiting, diarrhea, or rash. Your doctor
may be able to help you manage these symptoms. Your doctor will advise you whether your
symptoms can be managed on therapy or whether Agenerase should be stopped.
For more detailed information about Agenerase, ask your health care provider.