What is Actos
Actos, in addition to diet and exercise, improves
blood sugar control in patients with type 2 diabetes (non-insulin
dependent diabetes). Actos can
be used alone or in combination with a sulfonylurea, metformin, or insulin
when diet, exercise, and one of these agents or diet, exercise, plus Actos
alone are not are not enough to control blood sugar.
Who should not
Do not take Actos for Type 1 diabetes (juvenile diabetes) or diabetic
If you have heart failure, fluid retention or active liver disease your
health care provider will evaluate you to decide if Actos is right for
Reports of Patients? Experiences Since Actos Became Available:
have been reports of inflammation of the liver (hepatitis) and elevated
liver enzymes. It has not been
determined whether these events are directly related to Actos.
It is recommended that patients taking Actos have their liver
enzymes monitored periodically.
Precautions with Actos:
Actos is in the same class of
drugs as Rezulin, which has been associated with rare but serious liver
injury, including liver failure leading to transplant or death.
Because the liver safety profile of Actos is not fully determined
yet, your doctor will do blood tests that evaluate your liver before
starting you on Actos. These
blood tests should be repeated every two months for the first year, then
regularly after that.
your health care provider right away if you develop nausea, vomiting,
stomach pain, a feeling of tiredness or having no energy, loss of
appetite, dark urine, or jaundice (yellow coloring of eyes and skin).
These may be the symptoms of liver problems.
who experience an unusually rapid increase in weight or retain fluid
(edema) or who develop shortness of breath or other symptoms of heart
failure while on Actos should immediately report these symptoms to their
health care provider.
When taking Actos with insulin or certain other oral diabetes medicines,
there is a risk of your blood sugar becoming dangerously low.
Ask your health care provider about symptoms of low blood sugar,
conditions that make low blood sugar more likely, and what to do if you
get it. Make sure to explain
to family members.
If you are a woman who has not reached menopause but have
not had menstrual periods; you may become pregnant unless you use an
effective method of birth control. Actos,
like other drugs in this class, may cause insulin resistant women to start
Women should tell their doctor if they notice any changes in
their monthly menstrual cycle.
During periods of stress on the body, such as fever, trauma,
infection, or surgery, your medication requirements may change; contact
your health care provider promptly.
What should I
tell my doctor or health care provider?
Women taking oral birth control pills should talk to
their health care provider when taking Actos, because the effectiveness of
oral birth control pills can be reduced.
Tell your health care provider if you are trying to
become pregnant, are already pregnant, or are breast-feeding.
Because certain other medications may interact with
Actos, review all medications that you are taking with your health care
provider, including those that you take without a prescription.
What are some
possible side effects of Actos? (This
list is not a complete list of side effects reported with Actos.
Your health care provider can discuss with you a more complete list
of side effects.)
cough or cold
inflammation of the sinuses or throat
swelling or fluid retention
For more detailed information about Actos, ask your
health care provider.